• Molecular NameProgesterone
  • SynonymCorpus Luteum Hormone; Progesterona [INN-Spanish]; Progesteronum; Progesteronum [INN-Latin]
  • Weight314.469
  • Drugbank_IDDB00396
  • ACS_NO57-83-0
  • Show 3D model
  • LogP (experiment)3.87
  • LogP (predicted, AB/LogP v2.0)3.56
  • pkaN/A
  • LogD (pH=7, predicted)3.56
  • Solubility (experiment)0.00881 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.67
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds1
  • TPSA34.14
  • StatusFDA approved
  • AdministrationOral, implant
  • PharmacologyA C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestogens, and is the major naturally occurring human progestogen.
  • Absorption_value96.0
  • Absorption (description)Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.
  • Caco_2-4.37
  • Bioavailability20.0
  • Protein binding97.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic to pregnanediols and pregnanolones
  • Half life34.8~55.13 h
  • Excretionrenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityDizziness, breast pain, headache, abdominal pain, breast tenderness, joint pain, depression, abdominal bloating, hot flashes, urinary problems, vaginal discharge.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A