• Molecular NameLevonorgestrel
  • SynonymLevonorgestrelum [INN-Latin]; SOH-075
  • Weight312.453
  • Drugbank_IDDB00367
  • ACS_NO797-63-7
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  • LogP (experiment)3.251
  • LogP (predicted, AB/LogP v2.0)3.15
  • pkaN/A
  • LogD (pH=7, predicted)3.15
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.64
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors1
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds2
  • TPSA37.3
  • StatusFDA approved
  • AdministrationImplant; insert (extended-release); oral
  • PharmacologyA synthetic progestogen used as an active ingredient in some hormonal contraceptives.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability80.0
  • Protein binding95.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life5~14 h
  • ExcretionRenal: 45%; Fecal:32%
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityNausea, vomiting, and drowsiness/fatigue; Withdrawal bleeding;
  • LD50 (rat)N/A
  • LD50 (mouse)N/A