• Molecular NameDydrogesterone
  • Synonym10alpha-Isopregnenone; Didrogesterone [DCIT]; Dydrogesterona [INN-Spanish]; Dydrogesteronum [INN-Latin]; Hydrogesterone; Hydrogestrone; Isopregnenone
  • Weight312.453
  • Drugbank_IDDB00378
  • ACS_NO152-62-5
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.05
  • pkaN/A
  • LogD (pH=7, predicted)3.05
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.41
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds1
  • TPSA34.14
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA progestogen hormone.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability28.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolisation of dydrogesterone is virtually complete. The major metabolites are 20α-hydroxydydrogesterone and 21-hydroxydydrogesterone.
  • Half life5~7 h (dydrogesterone) & 14~17 h (DHD)
  • ExcretionAbout 50% of a dose is excreted in the urine in 24 h, as metabolites.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityNo serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route. There was no evidence of mutagenic potential in the Ames test.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A