• Molecular NamePraziquantel
  • SynonymNA
  • Weight312.413
  • Drugbank_IDDB01058
  • ACS_NO55268-74-1
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.63
  • pkaN/A
  • LogD (pH=7, predicted)2.63
  • Solubility (experiment)0.4 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.6
  • LogSw (predicted, AB/LogsW2.0)0.29
  • Sw (mg/ml) (predicted, ACD/Labs)0.08
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds1
  • TPSA40.62
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn anthelmintic effective against flatworms.
  • Absorption_value96.0
  • Absorption (description)Praziquantel is well (approximately 80%) absorbed from the gastrointestinal tract.
  • Caco_2N/A
  • Bioavailability7.0
  • Protein binding82.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPraziquantel is metabolized through the cytochrome P450 pathway 3A4. Agents that induce or inhibit Cyp450 3A4 (ie phenytoin, rifampin, azole antifungals) will have an effect the metabolism of praziquantel.
  • Half life0.8~1.5 h (Main Metabolites 4 to 5 hours)
  • ExcretionPraziquantel and its metabolites are mainly excreted in the urine, and within 24 hours after a single oral dose, 70 to 80% are found in urine, but less than 0.1% are found as the unchanged drug.
  • Urinary ExcretionNegligible
  • Clerance467 ml/min/kg (5 mg/kg) or 57~222 ml/min/kg (40~60 mg/kg)
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A