- Molecular NameDesogestrel
- SynonymDesogestrelum [INN-Latin]
- Weight310.481
- Drugbank_IDDB00304
- ACS_NO54024-22-5
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)4.64
- pkaN/A
- LogD (pH=7, predicted)4.64
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-6.26
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors1
- No.of HBond Acceptors1
- No.of Rotatable Bonds2
- TPSA20.23
- StatusFDA approved
- AdministrationN/A
- PharmacologyA molecule used in hormonal contraceptives.
- Absorption_value72.0
- Absorption (description)Following oral administration, the relative bioavailability of desogestrel compared to a solution, as measured by serum levels of etonogestrel, is approximately 100%.
- Caco_2N/A
- Bioavailability5.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmDesogestrel is rapidly and completely metabolized by hydroxylation in the intestinal mucosa and on first pass through the liver to etonogestrel. Other metabolites (i.e., 3a-OH-desogestrel, 3b-OH-desogestrel, and 3a-OH-5a-H-desogestrel) with no pharmacologic actions also have been identified and these metabolites may undergo glucuronide and sulfate conjugation.
- Half life27.8 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include nausea and vaginal bleeding.
- LD50 (rat)N/A
- LD50 (mouse)N/A