• Molecular NameNadolol
  • SynonymNA
  • Weight309.406
  • Drugbank_IDDB01203
  • ACS_NO42200-33-9
  • Show 2D model
  • LogP (experiment)0.81
  • LogP (predicted, AB/LogP v2.0)0.91
  • pkaN/A
  • LogD (pH=7, predicted)-1.56
  • Solubility (experiment)30.2 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.48
  • LogSw (predicted, AB/LogsW2.0)16.88
  • Sw (mg/ml) (predicted, ACD/Labs)3.59
  • No.of HBond Donors4
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds6
  • TPSA81.95
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA non-selective beta blocker used in the treatment of high blood pressure, migraine headaches, and chest pain.
  • Absorption_value32.0
  • Absorption (description)N/A
  • Caco_2-5.41
  • Bioavailability30.0
  • Protein binding14.0
  • Volume of distribution (VD)2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmNot metabolized by the liver and excreted unchanged primarily by the kidneys.
  • Half life6~24 h
  • ExcretionRenal and fecal (unchanged)
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=4500mg/kg