- Molecular NameMetipranolol
- SynonymMetipranolol hydrochloride; Metipranololum [INN-Latin]
- Weight309.406
- Drugbank_IDDB01214
- ACS_NO22664-55-7
- Show 3D model
- LogP (experiment)2.28
- LogP (predicted, AB/LogP v2.0)2.41
- pkaN/A
- LogD (pH=7, predicted)0.02
- Solubility (experiment)0.589 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.08
- LogSw (predicted, AB/LogsW2.0)7.07
- Sw (mg/ml) (predicted, ACD/Labs)1.19
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds8
- TPSA67.79
- StatusFDA approved
- AdministrationN/A
- PharmacologyA non-selective beta blocker used in eye drops to treat glaucoma.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe beta-blocking agent metipranolol is very rapidly metabolized in vivo to yield deacetylmetipranolol, which has a non-selective beta-receptor blocking activity.
- Half lifedesacetylmetipranolol 2~4 h but there is considerable intersubject variation.
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)LD50=31 (intravenous)