• Molecular NameFluoxetine
  • SynonymFluoxetina [INN-Spanish]; Fluoxetina [Spanish]; Fluoxetine Hcl; Fluoxetine Hydrochloride; Fluoxetinum [INN-Latin]
  • Weight309.331
  • Drugbank_IDDB00472
  • ACS_NO54910-89-3
  • Show 3D model
  • LogP (experiment)4.5
  • LogP (predicted, AB/LogP v2.0)4.64
  • pka8.7
  • LogD (pH=7, predicted)2.18
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.88
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.12
  • No.of HBond Donors1
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds7
  • TPSA21.26
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine is approved for the treatment of major depression (including pediatric depression), obsessive-compulsive disorder (in both adult and pediatric populations), bulimia nervosa, anorexia nervosa, panic disorder and premenstrual dysphoric disorder.
  • Absorption_value80.0
  • Absorption (description)Fluoxetine is readily absorbed after oral administration (> 80% of dose is absorbed)
  • Caco_2N/A
  • Bioavailability60.0
  • Protein binding94.0
  • Volume of distribution (VD)7 L/kg (between 20 and 42 L/kg for both fluoxetine and norfluoxetine).
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmExtensively metabolised in the liver by demethylation. The primary active metabolite is norfluoxetine, which is excreted via the kidneys. Further metabolism can occur by O-dealkylation producing p-trifluoromethylphenol and hippuric acid.
  • Half life53 h
  • Excretion80% of a drug dose is excreted in urine with less than 10% as the unchanged parent drug and 15% excreted in faeces. Fluoxetine is widely distributed throughout the body and secreted into breast milk.
  • Urinary Excretion<2.5
  • Clerance9.6 ml/min/kg
  • ToxicitySymptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. Blood concentrations of 1.3 to 6.8 mg/L fluoxetine and 0.9 to 5.0 mg/L norfluoxetine have been associated with fatalities. Serum levels of 1.96 mg/L fluoxetine (0.42 mg/L norfluoxetine) have been associated with seizures.
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=284mg/kg