• Molecular NameIndecainide
  • Synonym9-(3-(Isopropylamino)propyl)-9-fluorenylcarboxamid; 9-(3-(Isopropylamino)propyl))fluorene-9-carboxamide; Indecainida [Spanish]; Indecainidum [Latin]; Ricainid; Ricainide
  • Weight308.425
  • Drugbank_IDDB00192
  • ACS_NO74517-78-5
  • Show 3D model
  • LogP (experiment)3.11
  • LogP (predicted, AB/LogP v2.0)3.28
  • pkaN/A
  • LogD (pH=7, predicted)0.25
  • Solubility (experiment)0.00188 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.8
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.13
  • No.of HBond Donors3
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds6
  • TPSA55.12
  • StatusFDA approved; US withdrawn
  • AdministrationN/A
  • PharmacologyAn antiarrhythmic agent.
  • Absorption_value100.0
  • Absorption (description)Nearly complete following oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.
  • LD50 (rat)LD50=100 mg/kg
  • LD50 (mouse)LD50=100 mg/kg