• Molecular NamePhenylbutazone
  • SynonymNA
  • Weight308.381
  • Drugbank_IDDB00812
  • ACS_NO50-33-9
  • Show 2D model
  • LogP (experiment)3.16
  • LogP (predicted, AB/LogP v2.0)3.34
  • pka4.4
  • LogD (pH=7, predicted)3.34
  • Solubility (experiment)0.416 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.31
  • LogSw (predicted, AB/LogsW2.0)0.08
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds5
  • TPSA40.62
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyUsed as active ingredients in sunscreen formulations for protection against UVB rays.
  • Absorption_value98.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability90.0
  • Protein binding98.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life3 days (phenylbutazone), but dose-dependent and increased in subjects with renal failure and in the elderly; oxyphenbutazone about 2 to 3 days, 3′-hydroxyphenylbutazone about 32 h.
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)LD50=350
  • LD50 (mouse)LD50=700 (peroral); LD50=420