- Molecular NameWarfarin
- SynonymWarfarin sodium
- Weight308.333
- Drugbank_IDDB00682
- ACS_NO81-81-2
- Show 2D model
- LogP (experiment)2.6
- LogP (predicted, AB/LogP v2.0)3.06
- pka5
- LogD (pH=7, predicted)0.93
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.6
- LogSw (predicted, AB/LogsW2.0)0.09
- Sw (mg/ml) (predicted, ACD/Labs)0.04
- No.of HBond Donors1
- No.of HBond Acceptors4
- No.of Rotatable Bonds4
- TPSA63.6
- StatusFDA approved
- AdministrationOral or intravenous
- PharmacologyAn anticoagulant. It was initially marketed as a pesticide against rats and mice and is still popular for this purpose, although more potent poisons such as brodifacoum have since been developed. A few years after its introduction, warfarin was found to be effective and relatively safe for preventing thrombosis and embolism (abnormal formation and migration of blood clots) in many disorders. It was approved for use as a medication in the early 1950s and has remained popular ever since; warfarin is the most widely prescribed anticoagulant drug in North America.
- Absorption_value97.0
- Absorption (description)N/A
- Caco_2-4.68
- Bioavailability93.0
- Protein binding99.0
- Volume of distribution (VD)0.14 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic: CYP2C9, 2C19, 2C8, 2C18, 1A2 and 3A4
- Half life37 h
- ExcretionRenal (92%)
- Urinary Excretion<2
- Clerance0.045 ml/min/kg
- ToxicityLD50=374 (orally in mice)
- LD50 (rat)N/A
- LD50 (mouse)N/A