• Molecular NameFluconazole
  • SynonymNA
  • Weight306.276
  • Drugbank_IDDB00196
  • ACS_NO86386-73-4
  • Show 3D model
  • LogP (experiment)0.5
  • LogP (predicted, AB/LogP v2.0)0.63
  • pka2.03
  • LogD (pH=7, predicted)0.63
  • Solubility (experiment)4.85 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.13
  • LogSw (predicted, AB/LogsW2.0)1.97
  • Sw (mg/ml) (predicted, ACD/Labs)0.23
  • No.of HBond Donors1
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds5
  • TPSA81.65
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
  • Absorption_value94.0
  • Absorption (description)Fluconazole is well absorbed after oral administration and is widely distributed throughout the body.
  • Caco_2N/A
  • Bioavailability90.0
  • Protein binding11.0
  • Volume of distribution (VD)0.6 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic 11%
  • Half life32 h
  • Excretion80% of the parent drug is excreted unchanged in urine and 11% as metabolites.
  • Urinary Excretion75
  • Clerance0.27 ml/min/kg
  • ToxicityThe toxic serum concentration is 20 mg/L. Symptoms of overdose include hallucinations and paranoid behavior.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A