• Molecular NameMelphalan
  • SynonymNA
  • Weight305.205
  • Drugbank_IDDB01042
  • ACS_NO148-82-3
  • Show 3D model
  • LogP (experiment)-0.5
  • LogP (predicted, AB/LogP v2.0)-0.11
  • pka1.83; 9.13
  • LogD (pH=7, predicted)-0.11
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-2.17
  • LogSw (predicted, AB/LogsW2.0)1.42
  • Sw (mg/ml) (predicted, ACD/Labs)2.07
  • No.of HBond Donors3
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds8
  • TPSA66.56
  • StatusFDA approved
  • AdministrationOral, intravenous
  • PharmacologyA chemotherapy drug belonging to the class of nitrogen mustard alkylating agents.
  • Absorption_valueN/A
  • Absorption (description)Incomplete, variable, 25-89% post oral dose
  • Caco_2N/A
  • Bioavailability71.0
  • Protein binding90.0
  • Volume of distribution (VD)0.45 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHydrolysis
  • Half life1.4 h
  • ExcretionRenal, significantly metabolised
  • Urinary Excretion12
  • Clerance5.2 ml/min/kg
  • ToxicityVomiting, ulceration of the mouth, diarrhea, and hemorrhage of the gastrointestinal tract; The principal toxic effect is bone marrow suppression.
  • LD50 (rat)LD50=11.2 mg/kg
  • LD50 (mouse)N/A