- Molecular NameFlupirtine
- SynonymNA
- Weight304.325
- Drugbank_IDN/A
- ACS_NO56995-20-1
- Show 3D model
- LogP (experiment)2.66
- LogP (predicted, AB/LogP v2.0)2.78
- pkaN/A
- LogD (pH=7, predicted)2.75
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-3.53
- LogSw (predicted, AB/LogsW2.0)0.07
- Sw (mg/ml) (predicted, ACD/Labs)0.09
- No.of HBond Donors4
- No.of HBond Acceptors6
- No.of Rotatable Bonds6
- TPSA89.27
- StatusN/A
- AdministrationN/A
- PharmacologyAn aminopyridine.
- Absorption_valueN/A
- Absorption (description)Flupirtine is almost completely absorbed
- Caco_2N/A
- Bioavailability90.0
- Protein binding85.0
- Volume of distribution (VD)1.15 to 1.16 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmUndergoes oxidative degradation and acetylation of the hydrolysis product, in the liver, to two major metabolites; p-fluorohippuric acid and an acteylated metabolite, respectively.
- Half life8.5 to 10.7 h, depending on type of administration.
- Excretion72% of a dose is excreted in urine as the parent drug and as metabolites, and 18% in faeces. It is known to cross the blood–brain barrier and appears quickly in cerebrospinal fluid. Less than 0.005% of a dose is secreted in breast milk.
- Urinary ExcretionN/A
- Clerance16.5 L/h
- ToxicityModerately toxic by ingestion and subcutaneous routes.
- LD50 (rat)N/A
- LD50 (mouse)N/A