- Molecular NameCocaine
- SynonymBadrock; Bazooka; Benzoylethylecgonine; Benzoylmethylecgonine; Bernice; Bernies; Beta-Cocain; Blast; Blizzard; Blow; Bouncing Powder; Bump; Burese; C" Carrie; Cabello; Candy; Carrie; Caviar; Cecil; Charlie; Chicken Scratch; Cholly; COC; Coca; Cocain; Cocaina; Cocaine Free Base; Cocaine-M; Cocktail; Coke; Cola; Corine; D-pseudococaine; Dama Blanca; Delcaine; Depsococaine; Dextrocaine; Dust; Eritroxilina; Erytroxylin; Flake; Flex; Florida Snow; Foo Foo; Freeze; G-Rock; Girl; Gold Dust; Goofball; Green Gold; Happy Dust; Happy Powder; Happy Trails; Heaven; Hell; Isocaine; Isococain; Isococaine; Jam; Kibbles N' Bits; Kokain; Kokan; Kokayeen; L-Cocain; L-Cocaine; Lady; Leaf; Line; Methyl Benzoylecgonine; Moonrocks; Neurocaine; Pimp's Drug; Prime Time; Rock; Sleighride; Snort; Star Dust; Star-Spangled Powder; Sugar; Sweet Stuff; Toke; Toot; Trails; Yeyo; Zip
- Weight303.358
- Drugbank_IDDB00907
- ACS_NO50-36-2
- Show 2D model
- LogP (experiment)2.3
- LogP (predicted, AB/LogP v2.0)2.44
- pka8.6
- LogD (pH=7, predicted)0.88
- Solubility (experiment)1.71 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.05
- LogSw (predicted, AB/LogsW2.0)1.21
- Sw (mg/ml) (predicted, ACD/Labs)0.34
- No.of HBond Donors0
- No.of HBond Acceptors5
- No.of Rotatable Bonds5
- TPSA55.84
- StatusFDA approved
- AdministrationTopical, Oral, Insufflation, IV, PO
- PharmacologyA stimulant of the central nervous system and an appetite suppressant. Specifically, it is a serotonin-norepinephrine-dopamine reuptake inhibitor, which mediates functionality of such as an exogenous catecholamine transporter ligand.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability57.0
- Protein binding91.0
- Volume of distribution (VD)1~3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic CYP3A4. It is less toxic when taken orally owing to hydrolysis in the gastro-intestinal tract. The main metabolites are benzoylecgonine, ecgonine, and ecgonine methyl ester, all of which are inactive; some norcocaine, an active metabolite, may also be produced; other metabolites that have been reported are ethylecgonine, hydroxycocaine, and methylecgonidine. When taken in combination with alcohol, a cocaethylene metabolite is also produced.
- Half life0.7~1.5 h (dose-dependent).
- ExcretionAbout 1 to 9% of a daily intravenous dose of 120 mg of cocaine is excreted unchanged in the urine, together with 35 to 55% as benzoylecgonine; the excretion of unchanged drug is increased when the urine is acid; some ecgonine may also be present. After an intranasal dose of 1.5 mg/kg, up to 4% of the dose is excreted in the urine unchanged in 24 h, and 16 to 36% of the dose is excreted as benzoylecgonine. About 30 to 60% of an oral, intranasal, or intravenous dose is excreted in the urine as ecgonine methyl ester. Elimination of cocaine and metabolites in urine is typically complete within 48 h of dosing; in plasma, it is usually in the range of 18 to 24 h. No unchanged drug is eliminated in the faeces. Cocaine crosses the placenta and is found in breast milk.
- Urinary ExcretionN/A
- Clerance10~32 ml/min/kg (dose-dependent)
- ToxicityThe estimated minimum lethal dose is 1.2 g but susceptible persons have died from doses as small as 30 mg when applied to mucous membranes; addicts may be able to tolerate up to 5 g a day. Toxic effects have been noted with blood concentrations in the range 0.25 to 5 mg/L and fatalities have occurred with concentrations of 1 mg/L or more.
- LD50 (rat)N/A
- LD50 (mouse)N/A