• Molecular NameEthacrynic acid
  • SynonymEtacrinic acid; Etacrynic acid; Etakrinic acid; Ethacryinic Acid; Ethacrynate; Methylenebutyrylphenoxyacetic acid
  • Weight303.141
  • Drugbank_IDDB00903
  • ACS_NO58-54-8
  • Show 2D model
  • LogP (experiment)3.414
  • LogP (predicted, AB/LogP v2.0)3.52
  • pka3.5
  • LogD (pH=7, predicted)-0.31
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.32
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.16
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds6
  • TPSA63.6
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure.
  • Absorption_value90.0
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding98.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life0.5~1 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityOverdosage may lead to excessive diuresis with electrolyte depletion.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A