• Molecular NameBenoxaprofen
  • Synonym(1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid; 2-(2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl)propanoic acid; 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; 2-[2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid; Benoxaprofene [inn-french]; Benoxaprofeno [inn-spanish]; Benoxaprofenum [inn-latin]; DL-benoxaprofen
  • Weight301.729
  • Drugbank_IDN/A
  • ACS_NO67434-14-4
  • Show 2D model
  • LogP (experiment)3.2
  • LogP (predicted, AB/LogP v2.0)3.59
  • pka3.5
  • LogD (pH=7, predicted)0.88
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.33
  • LogSw (predicted, AB/LogsW2.0)0.02
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds3
  • TPSA63.33
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA non-steroidal anti-inflammatory drug.
  • Absorption_valueN/A
  • Absorption (description)Benoxaprofen is readily absorbed after oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding99.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life30~35 h
  • ExcretionAbout 15% of a dose is excreted in the urine in 24 h, mainly as the glucuronic acid conjugate, together with small amounts of unchanged drug. In 5 days about 60% of a dose is excreted in the urine and 40% is eliminated in the faeces.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityBecause of reports of adverse reactions and fatalities, benoxaprofen was withdrawn worldwide in 1982.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A