• Molecular NameTegaserod_maleate
  • SynonymSDZ HTF 919; tegaserod; Tegaserod
  • Weight301.394
  • Drugbank_IDN/A
  • ACS_NO189188-57-6
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.75
  • pkaN/A
  • LogD (pH=7, predicted)1.14
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.99
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.05
  • No.of HBond Donors4
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds9
  • TPSA85.29
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability11.0
  • Protein binding98.0
  • Volume of distribution (VD)5.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmEliminated primarily by metabolism (presystemic acid catalyzed hydrolysis in the stomach and direct glucuronidation).
  • Half life11 h
  • ExcretionFecal and renal
  • Urinary ExcretionNegligible
  • Clerance18 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)LD50=2000 mg/kg
  • LD50 (mouse)N/A