- Molecular NameChlorcyclizine
- SynonymNA
- Weight300.833
- Drugbank_IDN/A
- ACS_NO82-93-9
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)3.86
- pka2.4, 7.8
- LogD (pH=7, predicted)2.56
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.03
- LogSw (predicted, AB/LogsW2.0)0.27
- Sw (mg/ml) (predicted, ACD/Labs)0.66
- No.of HBond Donors0
- No.of HBond Acceptors2
- No.of Rotatable Bonds3
- TPSA6.48
- StatusN/A
- AdministrationN/A
- PharmacologyA piperazine antihistamine.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration and widely distributed throughout the body.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding87.5
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolised by N-demethylation to form norchlorcyclizine and by N-oxidation. High concentrations of the N-desmethyl metabolite are found in the liver, lungs, kidney, and spleen.
- Half life12 h (chlorcyclizine); 6~9 days (norchlorcyclizine)
- ExcretionSlowly excreted in the urine; measurable amounts of norchlorcyclizine have been detected in the urine for up to 3 weeks after the cessation of chronic oral administration. About 0.5% of a dose is excreted in the urine as the N-oxide.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A