- Molecular NameClobazam
- Synonymclobazam
- Weight300.745
- Drugbank_IDDB00349
- ACS_NO22316-47-8
- Show 2D model
- LogP (experiment)2.12
- LogP (predicted, AB/LogP v2.0)2.02
- pkaN/A
- LogD (pH=7, predicted)2.02
- Solubility (experiment)0.0996 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.88
- LogSw (predicted, AB/LogsW2.0)0.08
- Sw (mg/ml) (predicted, ACD/Labs)0.04
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds1
- TPSA40.62
- StatusFDA approved
- AdministrationN/A
- PharmacologyA drug which is a benzodiazepine derivative.
- Absorption_value100.0
- Absorption (description)Readily absorbed after oral administration; peak plasma concentrations reached after 1 to 4 h.
- Caco_2N/A
- Bioavailability90.0
- Protein binding85.0
- Volume of distribution (VD)1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised in the liver by demethylation and hydroxylation. Metabolites found in the serum include N-desmethylclobazam (norclobazam), which is thought to be active, 4′-hydroxyclobazam, and 4′-hydroxydesmethylclobazam.
- Half lifeclobazam 10~58 h (mean 25), desmethylclobazam, about 40 h. The half-life may be prolonged considerably in elderly subjects.
- ExcretionAbout 90% of a dose is excreted in the urine in 17 days and about 2% is eliminated in the faeces.
- Urinary ExcretionN/A
- Clerance0.5 ml/min/kg
- ToxicityUp to 300 mg has been ingested without serious toxic effects.
- LD50 (rat)N/A
- LD50 (mouse)N/A