• Molecular NameTestolactone
  • SynonymTestolactona [INN-Spanish]; Testolactonum [INN-Latin]; Testolattone [Dcit]
  • Weight300.398
  • Drugbank_IDDB00894
  • ACS_NO968-93-4
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.67
  • pkaN/A
  • LogD (pH=7, predicted)3.67
  • Solubility (experiment)0.0274 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.28
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds0
  • TPSA43.37
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antineoplastic agent that is a derivative of progesterone and is used to treat advanced stage breast cancer.
  • Absorption_valueN/A
  • Absorption (description)Testolactone is well absorbed from the gastrointestinal tract.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding85.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic. Metabolized to several derivatives in the liver, all of which preserve the lactone D-ring.
  • Half lifeN/A
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=1630 mg/kg