- Molecular NameMetoclopramide
- SynonymMetaclopramide; Metaclopromide; Methochlopramide; Methoclopramide; Metochlopramide; Metoclopramida [INN-Spanish]; metoclopramide; Metoclopramide Hcl; Metoclopramide Hydrochloride; Metoclopramidum [INN-Latin]
- Weight299.802
- Drugbank_IDDB01233
- ACS_NO364-62-5
- Show 3D model
- LogP (experiment)2.64
- LogP (predicted, AB/LogP v2.0)2.28
- pka9.3
- LogD (pH=7, predicted)0.11
- Solubility (experiment)0.2 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.3
- LogSw (predicted, AB/LogsW2.0)1.05
- Sw (mg/ml) (predicted, ACD/Labs)0.97
- No.of HBond Donors3
- No.of HBond Acceptors5
- No.of Rotatable Bonds7
- TPSA67.59
- StatusFDA approved
- AdministrationOral, IV, IM
- PharmacologyAn antiemetic and gastroprokinetic agent. Thus it is primarily used to treat nausea and vomiting, and to facilitate gastric emptying in patients with gastroparesis.
- Absorption_value88.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability76.0
- Protein binding40.0
- Volume of distribution (VD)3.4 L/kg but there is considerable intersubject variation.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic. The only common metabolite in these species is 2-[(4-amino-5-chloro-2-methoxybenzoyl)-aminolacetic acid. N-Deethylation is a major pathway for metoclopramide metabolism in the lower animals but not in humans. In humans, about one-half of the total radioactivity excreted was as a metoclopramide conjugates, indicating that this is a major route of excretion
- Half life5 h
- Excretion70–85% renal, 2% faecal
- Urinary Excretion20
- Clerance6.2 ml/min/kg
- ToxicitySigns of overdose include drowsiness, disorientation, and extrapyramidal reactions.
- LD50 (rat)N/A
- LD50 (mouse)LD50=280 mg/kg