- Molecular NameCycloserine
- Synonymalpha-Cycloserine; Cicloserina; D-CS; D-Cycloserine; (D-Cycloserine synth; BP 88); (D-Cycloserine; synthetic); D-Oxamicina; D-Oxamycin; DL-Cycloserine; L-Cycloserine
- Weight102.093
- Drugbank_IDDB00260
- ACS_NO68-41-7
- Show 3D model
- LogP (experiment)-1.7
- LogP (predicted, AB/LogP v2.0)-2.19
- pka4.5, 7.4
- LogD (pH=7, predicted)-3.83
- Solubility (experiment)99.8 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.93
- LogSw (predicted, AB/LogsW2.0)204.28
- Sw (mg/ml) (predicted, ACD/Labs)800.04
- No.of HBond Donors3
- No.of HBond Acceptors4
- No.of Rotatable Bonds0
- TPSA64.35
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn antibiotic effective against Mycobacterium tuberculosis. For the treatment of tuberculosis, it is classified as a second line drug, i.e. its use is only considered if one or more first line drugs cannot be used.
- Absorption_value72.0
- Absorption (description)Readily absorbed after oral administration and widely distributed throughout body fluids and tissues.
- Caco_2N/A
- Bioavailability80.0
- Protein binding20.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic
- Half life10 h
- ExcretionAbout 65% of a dose is excreted in the urine unchanged in 72 h, mostly in the first 24 h.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityA female subject who ingested a non-fatal overdose of 3 g, had a peak plasma concentration of 91 mg/L on admission to hospital; following peritoneal dialysis for 20 h, the plasma concentration declined to 25 mg/L. [R. Atkins et al.,BMJ,1965, 1, 907–908.]
- LD50 (rat)N/A
- LD50 (mouse)N/A