- Molecular NameHydrocodone
- SynonymDihydrocodeinone; Hidrocodona [INN-Spanish]; Hydrocodon; Hydrocodonum [INN-Latin]; Hydrocone; Hydroconum; Idrocodone [Dcit]
- Weight299.37
- Drugbank_IDDB00956
- ACS_NO125-29-1
- Show 2D model
- LogP (experiment)1.27
- LogP (predicted, AB/LogP v2.0)1.48
- pka8.3
- LogD (pH=7, predicted)0.39
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-1.47
- LogSw (predicted, AB/LogsW2.0)4.0
- Sw (mg/ml) (predicted, ACD/Labs)0.32
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds1
- TPSA38.77
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn orally active narcotic analgesic (pain reliever) and antitussive (cough suppressant).
- Absorption_valueN/A
- Absorption (description)Absorbed after oral administration.
- Caco_2N/A
- Bioavailability80.0
- Protein binding45.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe metabolism of hydrocodone to hydromorphone (more active) is catalyzed by CYP2D6.
- Half life4.24 (EM) and 6.16 (PM)
- ExcretionAbout 26% of a dose is excreted in the urine in 72 h, with 12% of the dose as unchanged drug, 5% as norhydrocodone, 4% as conjugated hydromorphone, 3% as 6-hydrocodol, and 0.1% as conjugated 6-hydromorphol. Hydrocodol and hydromorphol exist as stereoisomers. The unconjugated metabolites are thought to be active. Hydrocodone is a metabolite of codeine.
- Urinary Excretion10.2 (EM) and 18.1 (PM)
- Clerance11.1 ml/min/kg (EM) and 6.54 ml/min/kg (PM)
- ToxicityThe estimated lethal dose is 200 mg. Fatalities have occurred at blood concentrations greater than 0.1 mg/L.
- LD50 (rat)N/A
- LD50 (mouse)LD50=85.7mg/kg (subcutaneous, in mice).