• Molecular NameTrimeprazine
  • Synonym(+-)-Alimemazine; (+-)-Trimeprazine; Alimemazine; Alimemazine S,S-dioxide; Bayer 1219; Methylpromazine; Oxomemazin; Oxomemazina [INN-Spanish]; Oxomemazine; Oxomemazine [DCF:INN]; Oxomemazinum [INN-Latin]; Oxymemazine; Trimeperazine; Trimeprazine 5,5-dioxide; Trimeprazine hemi-(+)tartrate; Trimeprazine Tartrat; Trimeprazine Tartrate
  • Weight298.454
  • Drugbank_IDDB01246
  • ACS_NO84-96-8
  • Show 3D model
  • LogP (experiment)4.82
  • LogP (predicted, AB/LogP v2.0)4.82
  • pkaN/A
  • LogD (pH=7, predicted)2.67
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.75
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds4
  • TPSA31.78
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine). It also acts as a sedative and anti-emetic for prevention of motion sickness.
  • Absorption_value80.0
  • Absorption (description)Well absorbed in the digestive tract.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life5 hrs
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose clumsiness or unsteadiness, seizures, severe drowsiness, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath, shuffling walk, tic-like (jerky) movements of head and face, trembling and shaking of hands, and insomnia.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A