• Molecular NameTropisetron
  • SynonymNA
  • Weight298.386
  • Drugbank_IDN/A
  • ACS_NO89565-68-4
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.38
  • pkaN/A
  • LogD (pH=7, predicted)0.83
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.96
  • LogSw (predicted, AB/LogsW2.0)0.43
  • Sw (mg/ml) (predicted, ACD/Labs)0.1
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds3
  • TPSA34.47
  • StatusN/A
  • AdministrationOral, IV
  • PharmacologyA serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.
  • Absorption_value95.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability66.0
  • Protein binding65.0
  • Volume of distribution (VD)400 to 600 L
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (CYP3A4, CYP1A2, CYP2D6)
  • Half life7.3 h (intravenous), 8.6 h (oral) in extensive metabolisers; 30.3 h (intravenous) and 41.9 h (oral) in poor metabolisers.
  • ExcretionRenal, Fecal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A