- Molecular NameArtemether
- SynonymDihydroartemisinin methyl ether
- Weight298.379
- Drugbank_IDN/A
- ACS_NO71963-77-4
- Show 2D model
- LogP (experiment)2.86
- LogP (predicted, AB/LogP v2.0)3.07
- pkaN/A
- LogD (pH=7, predicted)3.07
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-3.53
- LogSw (predicted, AB/LogsW2.0)0.03
- Sw (mg/ml) (predicted, ACD/Labs)0.09
- No.of HBond Donors0
- No.of HBond Acceptors5
- No.of Rotatable Bonds1
- TPSA46.15
- StatusN/A
- AdministrationN/A
- PharmacologyAn antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.
- Absorption_valueN/A
- Absorption (description)Artemether is rapidly but incompletely absorbed after oral administration
- Caco_2N/A
- Bioavailability58.0
- Protein binding50.0
- Volume of distribution (VD)Apparent volume of distribution is 3.2 to 6.9 L/kg for patients with acute renal failure and 4.2 to 12.3 L/kg for those without.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolised in the liver to the demethylated derivative dihydroartemisinin (DHA).
- Half life1.5~3.5 h (artemether); 1.4~2.4 h (DHA)
- ExcretionIt is rapidly eliminated. Oral bioavailability, after intramuscular injection, is approx. 43%.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A