- Molecular NameFenclofenac
- SynonymNA
- Weight297.137
- Drugbank_IDN/A
- ACS_NO34645-84-6
- Show 2D model
- LogP (experiment)4.8
- LogP (predicted, AB/LogP v2.0)4.69
- pka5.5
- LogD (pH=7, predicted)1.88
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.04
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds4
- TPSA46.53
- StatusN/A
- Administrationoral, rectal, im, iv (renal- and gallstones), topical
- PharmacologyA non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in conditions such as arthritis or acute injury. It can also be used to reduce menstrual pain, dysmenorrhea.
- Absorption_value100.0
- Absorption (description)Well absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding99.0
- Volume of distribution (VD)0.2 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, about 1.7.
- MetabollsmHepatic, no active metabolites exist
- Half life26 h
- ExcretionMore than 90% of a dose is excreted in the urine in the form of conjugates of the drug and hydroxylated metabolites.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityFenclofenac was used in rheumatic disorders but it had a high incidence of adverse effects, especially skin reactions, and was withdrawn from the market.
- LD50 (rat)LD50=2500 (po)
- LD50 (mouse)N/A