- Molecular NameDisulfiram
- SynonymDisulfuram; Disulphuram; Dupon 4472; Dupont Fungicide 4472; TATD; TETD; Tetraethylthioperoxydicarbonic Diamide; Tetraethylthiram Disulfide; Tetraethylthiram Disulphide; Tetraethylthiuram; Tetraethylthiuram Disulfide; Tetraethylthiuram Disulphide; Tetraethylthiuram Sulfide; Tetraethylthiuran Disulfide; TTD; Usaf B-33
- Weight296.548
- Drugbank_IDDB00822
- ACS_NO97-77-8
- Show 2D model
- LogP (experiment)3.88
- LogP (predicted, AB/LogP v2.0)3.45
- pkaN/A
- LogD (pH=7, predicted)3.45
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-5.11
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors0
- No.of HBond Acceptors2
- No.of Rotatable Bonds9
- TPSA121.26
- StatusFDA approved
- AdministrationOral, subdermal implant
- PharmacologyA drug used to support the treatment of chronic alcoholism by producing an
- Absorption_value97.0
- Absorption (description)Disulfiram is incompletely absorbed after oral administration; the maximum effect usually occurs about 12 h after ingestion, possibly because it is highly lipid soluble and is likely to be initially localised in fat.
- Caco_2N/A
- Bioavailability80.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe metabolites include diethyldithiocarbamic acid, methyl diethyldithiocarbamate, diethylamine, carbon disulfide, and inorganic sulfate; glucuronide conjugation may occur.
- Half lifedisulfiram 7 h, diethyldithiocarbamic acid about 15 h, carbon disulfide about 9 h.
- ExcretionUp to about 20% of a dose is eliminated unchanged in the faeces, up to 50% of a dose may be excreted from the lungs as carbon disulfide, and the remainder is slowly excreted as metabolites in the urine; about 20% of a dose is still present in the body up to 7 days after ingestion.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySevere toxic reactions may occur after administration of disulfiram if the blood concentration of acetaldehyde is greater than 5 mg/L; with very high concentrations of alcohol in the blood the administration of as little as 0.5 to 1 g of disulfiram has proved fatal in some cases. Fatalities due to disulfiram-induced hepatitis have been reported and there have also been reports of severe phenytoin intoxication after simultaneous administration.
- LD50 (rat)LD50=8.6g/kg
- LD50 (mouse)N/A