• Molecular NameEthinylestradiol
  • Synonym17 alpha-Ethinylestradiol; 17 alpha-Ethynylestradiol; 17 alpha-Ethynyloestradiol; Aethinyloestradiolum; Aethinyoestradiol [German]; EE; EO; Ethinyl-Oestranol; Ethinylestradiolum [INN-Latin]; Ethinylestriol; Ethinyloestradiol; Ethynyl estradiol; Ethynylestradiol; Ethynyloestradiol; Etinilestradiol [INN-Spanish]
  • Weight296.41
  • Drugbank_IDDB00977
  • ACS_NO57-63-6
  • Show 2D model
  • LogP (experiment)3.67
  • LogP (predicted, AB/LogP v2.0)3.54
  • pka10.25
  • LogD (pH=7, predicted)3.54
  • Solubility (experiment)0.0149 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-5.18
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors2
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds1
  • TPSA40.46
  • StatusFDA approved
  • AdministrationOral, transdermal
  • PharmacologyA derivative of estradiol. Ethinyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills (the Pill). It is one of the most commonly used medications.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability43.0
  • Protein binding97.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.
  • Half life36 h
  • ExcretionFeces and Urine
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50: 1737 mg/kg