- Molecular NameDiclofenac
- SynonymDiclofenac Acid; Diclofenac Potassium; Diclofenac Sodium; ISV-205
- Weight296.153
- Drugbank_IDDB00586
- ACS_NO15307-86-5
- Show 2D model
- LogP (experiment)4.4
- LogP (predicted, AB/LogP v2.0)4.65
- pka4.15
- LogD (pH=7, predicted)2.03
- Solubility (experiment)0.00235 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.81
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.02
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds4
- TPSA49.33
- StatusFDA approved
- Administrationoral, rectal, im, iv (renal- and gallstones), topical
- PharmacologyA non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in conditions such as arthritis or acute injury. It can also be used to reduce menstrual pain, dysmenorrhea.
- Absorption_value100.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability54.0
- Protein binding99.5
- Volume of distribution (VD)0.17 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsmhepatic, Diclofenac is oxidated by CYP 2C8, 2C9, 2C18, 2C19 and 3A4 to different hydroxyderivatives including pharmacologically active in liver and conjugated with glucuronate by UGT2B7 and glutatione by CYP3A4 in initial and oxidized form respectively.
- Half life1.1 h; synovial fluid half-life 3~6 h
- Excretionbiliary, only 1% in urine
- Urinary Excretion<1
- Clerance4.2 ml/min/kg
- ToxicitySymptoms of overdose include loss of consciousness, increased intracranial pressure, and aspiration pneumonitis.
- LD50 (rat)N/A
- LD50 (mouse)LD50=390mg/kg