• Molecular NamePizotyline
  • SynonymPizotifen
  • Weight295.45
  • Drugbank_IDN/A
  • ACS_NO15574-96-6
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.9
  • pkaN/A
  • LogD (pH=7, predicted)2.3
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.78
  • LogSw (predicted, AB/LogsW2.0)0.08
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors0
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds0
  • TPSA31.48
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA benzocycloheptane based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches.
  • Absorption_value80.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability78.0
  • Protein binding91.0
  • Volume of distribution (VD)6.9 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmGlucuronidation (main route). N-glucuronide accounts for >50% of plasma and 60–70% of urinary excreted drug
  • Half lifeN/A
  • Excretion18% feces, 55% urine (both as metabolites).
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A