- Molecular NameDosulepin
- Synonymdothiepin
- Weight295.45
- Drugbank_IDN/A
- ACS_NO113-53-1
- Show 3D model
- LogP (experiment)4.52
- LogP (predicted, AB/LogP v2.0)4.8
- pka9.25
- LogD (pH=7, predicted)3.02
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.99
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.03
- No.of HBond Donors0
- No.of HBond Acceptors1
- No.of Rotatable Bonds3
- TPSA28.54
- StatusN/A
- AdministrationN/A
- PharmacologyAn antidepressant of the tricyclic family.
- Absorption_value95.0
- Absorption (description)Well absorbed after oral administration.
- Caco_2N/A
- Bioavailability30.0
- Protein binding84.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)Plasma:whole blood ratio, about 1.4.
- MetabollsmThe main metabolic reactions are demethylation to desmethyldosulepin (northiaden) and oxidation to dosulepin sulfoxide.
- Half life22 h, monodesmethyldosulepin 33 h, dosulepin sulfoxide 20 h
- ExcretionAbout 50 to 60% of a dose is excreted in the urine in 24 h, mainly as metabolites, and 15 to 40% of a dose is eliminated in the faeces in the same period. Enterohepatic circulation has been reported. Small amounts may be excreted in breast milk
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityFatalities have been associated with blood concentrations of 1 to 5 to 19 mg/L.
- LD50 (rat)N/A
- LD50 (mouse)N/A