• Molecular NameTertatolol
  • SynonymNA
  • Weight295.447
  • Drugbank_IDN/A
  • ACS_NO34784-64-0
  • Show 3D model
  • LogP (experiment)2.5
  • LogP (predicted, AB/LogP v2.0)3.29
  • pka9.8
  • LogD (pH=7, predicted)0.82
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.56
  • LogSw (predicted, AB/LogsW2.0)0.87
  • Sw (mg/ml) (predicted, ACD/Labs)0.36
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds6
  • TPSA66.79
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA medication in the class of beta blockers, used in the treatment of high blood pressure.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability60.0
  • Protein binding95.0
  • Volume of distribution (VD)30~40 L (0.7 L/kg); increased to 50 L in patients with cirrhosis.
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmTertatolol is extensively metabolized (99%) to 9 metabolites with three equally important pathways, sulfoxidation, hydroxylation and conjugation.
  • Half life3 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=37 (intravenous)