• Molecular NameProparacaine
  • SynonymProparacaine Hcl; Prossimetacaina [Dcit]; Proximetacaina [INN-Spanish]; Proximetacainum; Proxymetacaine; Proxymetacaine Hcl; Proxymetacainum [INN-Latin]
  • Weight294.395
  • Drugbank_IDDB00807
  • ACS_NO499-67-2
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.44
  • pkaN/A
  • LogD (pH=7, predicted)1.63
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.85
  • LogSw (predicted, AB/LogsW2.0)0.34
  • Sw (mg/ml) (predicted, ACD/Labs)0.32
  • No.of HBond Donors2
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds10
  • TPSA64.79
  • StatusFDA approved
  • AdministrationTopical (eye drops)
  • PharmacologyA topical anesthetic drug of the amino ester group. It is indicated for use as an ophthalmic anesthetic (as eye drops) to reduce pain and discomfort during procedures involving the eye. Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPlasma
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A