- Molecular NameButriptyline
- SynonymNA
- Weight293.454
- Drugbank_IDN/A
- ACS_NO35941-65-2
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)5.64
- pkaN/A
- LogD (pH=7, predicted)2.91
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.71
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.04
- No.of HBond Donors0
- No.of HBond Acceptors1
- No.of Rotatable Bonds4
- TPSA3.24
- StatusN/A
- AdministrationN/A
- PharmacologyA psychoactive drug of the tricyclic antidepressant (TCA) chemical class with antidepressant, anxiolytic, and sedative effects. Its actions are similar to those of amitriptyline.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding90.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is rapidly metabolised, and the metabolites are thought to undergo enterohepatic circulation; the major metabolite is norbutriptyline.
- Half life20 h
- ExcretionButriptyline is slowly excreted in the urine mainly as metabolites; up to 25% of a dose is excreted in the urine in 24 h with less than 2% of the dose as unchanged drug, and about 4% as glucuronide conjugates; about 1 to 2% of a dose is eliminated in the faeces in 24 h.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLD50=135 (mouse)
- LD50 (rat)N/A
- LD50 (mouse)N/A