• Molecular NameBrimonidine
  • SynonymBrimonidine tartrate; Bromoxidine
  • Weight292.14
  • Drugbank_IDDB00484
  • ACS_NO59803-98-4
  • Show 2D model
  • LogP (experiment)0.782
  • LogP (predicted, AB/LogP v2.0)1.47
  • pkaN/A
  • LogD (pH=7, predicted)-1.55
  • Solubility (experiment)1.5 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.87
  • LogSw (predicted, AB/LogsW2.0)0.68
  • Sw (mg/ml) (predicted, ACD/Labs)0.58
  • No.of HBond Donors2
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds2
  • TPSA62.2
  • StatusFDA approved
  • AdministrationOcular, 1 gtt
  • PharmacologyA drug used to treat open-angle glaucoma or ocular hypertension. Alphagan is also used to induce miosis for people suffering from poor night vision after Lasik or PRK surgery.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized primarily by the liver. Approximately 87% of an orally-administered dose was eliminated within 120 hours, with 74% found in the urine.
  • Half life2 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityOral LD50 is 50 mg/kg in mice and 100 mg/kg in rats.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A