• Molecular NamePenbutolol
  • SynonymPenbutolol sulfate
  • Weight291.435
  • Drugbank_IDDB01359
  • ACS_NO36507-48-9
  • Show 3D model
  • LogP (experiment)4.15
  • LogP (predicted, AB/LogP v2.0)3.89
  • pkaN/A
  • LogD (pH=7, predicted)1.41
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.68
  • LogSw (predicted, AB/LogsW2.0)2.06
  • Sw (mg/ml) (predicted, ACD/Labs)0.25
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds7
  • TPSA41.49
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA medication in the class of beta blockers, used in the treatment of high blood pressure.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability90.0
  • Protein binding89.0
  • Volume of distribution (VD)5.1 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPenbutolol is extensively metabolized in the liver by hydroxylation and glucuronidation. Active metabolites have not been identified
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A