- Molecular NameLindane
- SynonymNA
- Weight290.832
- Drugbank_IDDB00431
- ACS_NO58-89-9
- Show 2D model
- LogP (experiment)3.55
- LogP (predicted, AB/LogP v2.0)3.79
- pkaN/A
- LogD (pH=7, predicted)3.79
- Solubility (experiment)0.0073 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-4.67
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors0
- No.of HBond Acceptors0
- No.of Rotatable Bonds0
- TPSA0.0
- StatusFDA approved
- AdministrationTopical
- PharmacologyAn organochlorine chemical variant of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for infestations of lice and scabies.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after ingestion, inhalation, or through the skin. It is stored in the body fat and adrenal glands.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding91.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic cytochrome P-450 oxygenase system. Metabolised by oxidation and dehydrohalogenation to a series of chlorinated phenols which are excreted mainly in the urine in free and conjugated form.
- Half life26 h (Derived from urinary excretion data)
- ExcretionAfter intravenous administration, about 25% of the dose is excreted in the urine; after topical administration about 10% of the dose is recovered in the urine.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLindane is not highly toxic when applied externally in the concentrations usually employed (0.1 to 1%), but when ingested it may cause convulsions; dusts may irritate the nose and throat when used in a confined space. Blood concentrations greater than 0.02 mg/L have been associated with toxic effects. The estimated minimum oral lethal dose is 200 mg/kg and the maximum permissible atmospheric concentration is 0.5 mg/m3. Toxic doses or long-term exposure may cause liver necrosis. The maximum acceptable daily intake is 10 μg/kg.
- LD50 (rat)LD50=88~190 mg/kg
- LD50 (mouse)N/A