• Molecular NameFomepizole
  • SynonymN/A
  • Weight82.1038
  • Drugbank_IDDB01213
  • ACS_NO7554-65-6
  • Show 3D model
  • LogP (experiment)0.82
  • LogP (predicted, AB/LogP v2.0)0.97
  • pka2.91
  • LogD (pH=7, predicted)0.97
  • Solubility (experiment)Soluble
  • LogS (predicted, ACD/Labs)(ph=7)-1.3
  • LogSw (predicted, AB/LogsW2.0)19.35
  • Sw (mg/ml) (predicted, ACD/Labs)4.1
  • No.of HBond Donors1
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds0
  • TPSA28.68
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antidote in confirmed or suspected methanol or ethylene glycol poisoning. It may be used alone or in combination with hemodialysis.
  • Absorption_value0.0
  • Absorption (description)Rapid and complete
  • Caco_20.0
  • Bioavailability0.0
  • Protein binding0.0
  • Volume of distribution (VD)0.6 to 0.7 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPrimarily hepaticm the primary metabolite is 4-carboxypyrazole (approximately 80 to 85% of an administered dose). Other metabolites include 4-hydroxymethylpyrazole and the N -glucuronide conjugates of 4-carboxypyrazole and 4-hydroxymethylpyrazole.
  • Half lifeApprox. 5.2 h.
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityHeadache, nausea, dizziness
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=337 mg/kg