• Molecular NameHyoscyamine
  • SynonymHyocyamine; L-Atropine; L-Hyopscyamine; L-Hyoscamine; L-Hyoscyamine; L-Tropine Tropate
  • Weight289.375
  • Drugbank_IDDB00424
  • ACS_NO101-31-5
  • Show 3D model
  • LogP (experiment)1.83
  • LogP (predicted, AB/LogP v2.0)2.05
  • pka9.7
  • LogD (pH=7, predicted)-0.48
  • Solubility (experiment)3.56 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.54
  • LogSw (predicted, AB/LogsW2.0)3.65
  • Sw (mg/ml) (predicted, ACD/Labs)2.68
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds5
  • TPSA49.77
  • StatusFDA approved
  • AdministrationOral, Injection
  • PharmacologyA tropane alkaloid.
  • Absorption_valueN/A
  • Absorption (description)Absorbed totally and completely by sublingual administration as well as oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding50.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life3~5 h
  • ExcretionUrine
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include headache, nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation.
  • LD50 (rat)LD50=mg/kg
  • LD50 (mouse)N/A