- Molecular NameAdrafinil
- SynonymNA
- Weight289.355
- Drugbank_IDN/A
- ACS_NO63547-13-7
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.27
- pkaN/A
- LogD (pH=7, predicted)1.25
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.78
- LogSw (predicted, AB/LogsW2.0)0.27
- Sw (mg/ml) (predicted, ACD/Labs)0.45
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds5
- TPSA85.61
- StatusN/A
- AdministrationN/A
- PharmacologyA mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding80.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsm75% Hepatic. adrafinil is partly metabolised to its amide, 2-(benzhydrylsulfinyl)acetamide/2-[(diphenylmethyl)sulfinyl]acetamide (modafinil), which is also metabolised into its inactive acid and sulfone forms.
- Half lifeElimination half-life, adrafinil 1 h; modafinil 3 h
- ExcretionRenal
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLow toxicity.
- LD50 (rat)N/A
- LD50 (mouse)N/A