- Molecular NameTestosterone
- SynonymDea No; 4000; TES; Testosteron; Testosterona [INN-Spanish]; testosterone; Testosterone Cypionate; Testosterone Enanthate; Testosterone Hydrate; Testosteronum [INN-Latin]; Testostosterone; Trans-Testosterone
- Weight288.431
- Drugbank_IDDB00624
- ACS_NO58-22-0
- Show 2D model
- LogP (experiment)3.32
- LogP (predicted, AB/LogP v2.0)3.02
- pkaN/A
- LogD (pH=7, predicted)3.02
- Solubility (experiment)0.024 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-4.36
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors1
- No.of HBond Acceptors2
- No.of Rotatable Bonds0
- TPSA37.3
- StatusFDA approved
- AdministrationIntramuscular injection, transdermal (cream, gel, or patch), sub-'Q' pellet
- PharmacologyA steroid hormone from the androgen group. In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands.
- Absorption_value100.0
- Absorption (description)Approximately 10% of the testosterone dose applied on the skin surface is absorbed into systemic circulation
- Caco_2-4.34
- Bioavailability4.0
- Protein binding99.0
- Volume of distribution (VD)1.03 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmTestosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).
- Half life2~4 h
- ExcretionUrine (90%), feces (6%)
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySide effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.
- LD50 (rat)N/A
- LD50 (mouse)N/A