• Molecular NamePentazocine
  • SynonymL-pentazocine; Pentazocaine; Pentazocin
  • Weight285.431
  • Drugbank_IDDB00652
  • ACS_NO359-83-1
  • Show 2D model
  • LogP (experiment)3.31
  • LogP (predicted, AB/LogP v2.0)3.65
  • pka8.5, 10.0
  • LogD (pH=7, predicted)2.56
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.4
  • LogSw (predicted, AB/LogsW2.0)0.24
  • Sw (mg/ml) (predicted, ACD/Labs)0.23
  • No.of HBond Donors1
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds2
  • TPSA23.47
  • StatusFDA approved
  • AdministrationOral, Insufflation, IV, IM
  • PharmacologyA synthetically-prepared prototypical mixed agonist-antagonist narcotic (opioid analgesic) drug of the benzomorphan class of opioids used to treat mild to moderately severe pain.
  • Absorption_value95.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability18.0
  • Protein binding60.0
  • Volume of distribution (VD)4.5 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life4 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=190.1 (subcutaneous)