• Molecular NameHydromorphone
  • SynonymDihydromorfinon [Czech]; Dihydromorphinone; Hidromorfona [INN-Spanish]; Hydromorfona [Spanish]; Hydromorphon; Hydromorphone HCL; Hydromorphonum [INN-Latin]
  • Weight285.343
  • Drugbank_IDDB00327
  • ACS_NO466-99-9
  • Show 2D model
  • LogP (experiment)0.92
  • LogP (predicted, AB/LogP v2.0)1.25
  • pka8.08; 9.4796
  • LogD (pH=7, predicted)0.15
  • Solubility (experiment)Soluble
  • LogS (predicted, ACD/Labs)(ph=7)-1.03
  • LogSw (predicted, AB/LogsW2.0)1.35
  • Sw (mg/ml) (predicted, ACD/Labs)2.35
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds0
  • TPSA49.77
  • StatusFDA approved
  • Administrationoral, intramuscular, intravenous, subcutaneous, intranasal, rectal, sublingual, transmucosal, buccal, transcutaneous (experimental)
  • PharmacologyIt is both medically an opiate analgesic and legally a narcotic.
  • Absorption_valueN/A
  • Absorption (description)Rapidly but incompletely absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability42.0
  • Protein binding7.1
  • Volume of distribution (VD)2.90 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmExtensively metabolized. The principal metabolite, 3-glucuronide, accumulates to much higher (27-fold) levels than parent drug and may contribute to some side effects (not antinociceptive).
  • Half life2.4 h
  • ExcretionAbout 6% of a dose is excreted in the urine in 24 h as free hydromorphone with about 30% as conjugated hydromorphone and only traces of the active 6α- and 6β-hydroxy metabolites. It crosses the placenta. Hydromorphone is a metabolite of hydrocodone.
  • Urinary Excretion6
  • Clerance14.6 ml/min/kg
  • ToxicityHydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A