• Molecular NameMazindol
  • SynonymNA
  • Weight284.746
  • Drugbank_IDDB00579
  • ACS_NO22232-71-9
  • Show 3D model
  • LogP (experiment)2.835
  • LogP (predicted, AB/LogP v2.0)2.87
  • pka8.6
  • LogD (pH=7, predicted)0.07
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-1.07
  • LogSw (predicted, AB/LogsW2.0)0.02
  • Sw (mg/ml) (predicted, ACD/Labs)6.98
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds1
  • TPSA35.83
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA central nervous system stimulant.
  • Absorption_valueN/A
  • Absorption (description)Mazindol is absorbed after oral administration
  • Caco_2N/A
  • Bioavailability93.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life10~13 h
  • ExcretionSlowly excreted in the urine, partly unchanged and partly as metabolites.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of a mazindol overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.
  • LD50 (rat)LD50>400 (peroral)
  • LD50 (mouse)N/A