• Molecular NameIndoprofen
  • SynonymNA
  • Weight281.311
  • Drugbank_IDN/A
  • ACS_NO31842-01-0
  • Show 3D model
  • LogP (experiment)2.77
  • LogP (predicted, AB/LogP v2.0)2.63
  • pka5.8
  • LogD (pH=7, predicted)-0.07
  • Solubility (experiment)0.00426 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.11
  • LogSw (predicted, AB/LogsW2.0)0.07
  • Sw (mg/ml) (predicted, ACD/Labs)0.09
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds3
  • TPSA57.61
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA non-steroidal anti-inflammatory drug.
  • Absorption_value100.0
  • Absorption (description)Rapidly and almost completely absorbed after oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding99.0
  • Volume of distribution (VD)0.1 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life2 h
  • ExcretionAbout 80 to 90% of a dose is excreted in the urine in 24 h as the glucuronide conjugate together with small amounts of unchanged drug and metabolites.
  • Urinary ExcretionN/A
  • Clerance0.7 ml/min/kg
  • ToxicityIndoprofen was suspended from use in the United Kingdom in December 1983 because of reports of side-effects and fatalities.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A