- Molecular NameGuanidine
- SynonymAminomethanamidine; Carbamamidine; Carbamidine; Guanidin; Guanidine Hydrochloride; Guanidinium Chloride; Guanidinium Sulfate; Imidourea; Iminourea
- Weight59.072
- Drugbank_IDDB00536
- ACS_NO113-00-8
- Show 3D model
- LogP (experiment)-0.946
- LogP (predicted, AB/LogP v2.0)-1.19
- pkaN/A
- LogD (pH=7, predicted)-4.29
- Solubility (experiment)500 mg/ml (HCl salt)
- LogS (predicted, ACD/Labs)(ph=7)1.23
- LogSw (predicted, AB/LogsW2.0)10.17
- Sw (mg/ml) (predicted, ACD/Labs)987.7
- No.of HBond Donors5
- No.of HBond Acceptors3
- No.of Rotatable Bonds0
- TPSA75.89
- StatusFDA approved
- AdministrationN/A
- PharmacologyGuanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed and distributed
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmNot metabolized.
- Half life7~8 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityCan cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
- LD50 (rat)LD50 = 475 mg/kg
- LD50 (mouse)N/A