• Molecular NameOndansetron
  • SynonymNA
  • Weight279.343
  • Drugbank_IDDB00904
  • ACS_NO99614-02-5
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.38
  • pka7.4
  • LogD (pH=7, predicted)3.1
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.9
  • LogSw (predicted, AB/LogsW2.0)0.02
  • Sw (mg/ml) (predicted, ACD/Labs)0.23
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds2
  • TPSA39.82
  • StatusFDA approved
  • AdministrationOral, rectal, IV, IM
  • PharmacologyA serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy.
  • Absorption_value100.0
  • Absorption (description)The absorption of omeprazole takes place in the small intestine and is usually completed within 3–6 hours.
  • Caco_2N/A
  • Bioavailability62.0
  • Protein binding73.0
  • Volume of distribution (VD)1.9 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (CYP3A4, CYP1A2, CYP2D6)
  • Half life3.5 h
  • ExcretionRenal
  • Urinary Excretion5
  • Clerance5.9 ml/min/kg
  • ToxicityLow blood pressure and fainting, sudden blindness, severe constipation
  • LD50 (rat)N/A
  • LD50 (mouse)N/A