• Molecular NameTriprolidine
  • SynonymNA
  • Weight278.399
  • Drugbank_IDDB00427
  • ACS_NO486-12-4
  • Show 3D model
  • LogP (experiment)3.9
  • LogP (predicted, AB/LogP v2.0)3.74
  • pka6.5
  • LogD (pH=7, predicted)1.42
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.15
  • LogSw (predicted, AB/LogsW2.0)0.18
  • Sw (mg/ml) (predicted, ACD/Labs)0.27
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds4
  • TPSA16.13
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn over-the-counter antihistamine. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed in the intestinal tract.
  • Caco_2N/A
  • Bioavailability4.0
  • Protein binding90.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (CYP2D6)
  • Half life5 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include drowsiness, weakness, inco-ordination, difficulty with micturition, respiratory depression, hypotension, agitation, irritability, convulsions, hypertension, palpitation and tachycardia.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A